An inherited NBN mutation is associated with poor prognosis prostate cancer

BACKGROUND: To establish the contribution of eight founder alleles in three DNA damage repair genes (BRCA1, CHEK2 and NBS1) to prostate cancer in Poland, and to measure the impact of these variants on survival among patients. METHODS: Three thousand seven hundred fifty men with prostate cancer and 3...

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Detalhes bibliográficos
Main Authors: Cybulski, C, Wokołorczyk, D, Kluźniak, W, Jakubowska, A, Górski, B, Gronwald, J, Huzarski, T, Kashyap, A, Byrski, T, Dębniak, T, Gołąb, A, Gliniewicz, B, Sikorski, A, Świtała, J, Borkowski, T, Borkowski, A, Antczak, A, Wojnar, Ł, Przybyła, J, Sosnowski, M, Małkiewicz, B, Zdrojowy, R, Sikorska-Radek, P, Matych, J, Wilkosz, J, Różański, W, Kiś, J, Bar, K, Bryniarski, P, Paradysz, A, Jersak, K, Niemirowicz, J, Słupski, P, Jarzemski, P, Skrzypczyk, M, Dobruch, J, Domagała, P, Narod, S A, Lubiński, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Genetics & Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566821/
https://ncbi.nlm.nih.gov/pubmed/23149842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.486
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