Pharmacological Blockade of the Cold Receptor TRPM8 Attenuates Autonomic and Behavioral Cold Defenses and Decreases Deep Body Temperature

We studied N-(2-aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride (M8-B), a selective and potent antagonist of the transient receptor potential melastatin-8 (TRPM8) channel. In vitro, M8-B blocked cold-induced and TRPM8-agonist-induced activation of rat, human, and m...

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Hoofdauteurs: Almeida, M. Camila, Hew-Butler, Tamara, Soriano, Renato N., Rao, Sara, Wang, Weiya, Wang, Judy, Tamayo, Nuria, Oliveira, Daniela L., Nucci, Tatiane B., Aryal, Prafulla, Garami, Andras, Bautista, Diana, Gavva, Narender R., Romanovsky, Andrej A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Society for Neuroscience 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566779/
https://ncbi.nlm.nih.gov/pubmed/22323721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5606-11.2012
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