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Systems Modelling of NHEJ Reveals the Importance of Redox Regulation of Ku70/80 in the Dynamics of DNA Damage Foci

The presence of DNA double-stranded breaks in a mammalian cell typically activates the Non-Homologous End Joining (NHEJ) pathway to repair the damage and signal to downstream systems that govern cellular decisions such as apoptosis or senescence. The signalling system also stimulates effects such as...

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書誌詳細
主要な著者: Dolan, David, Nelson, Glyn, Zupanic, Anze, Smith, Graham, Shanley, Daryl
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566652/
https://ncbi.nlm.nih.gov/pubmed/23457464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055190
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