Systems Modelling of NHEJ Reveals the Importance of Redox Regulation of Ku70/80 in the Dynamics of DNA Damage Foci

The presence of DNA double-stranded breaks in a mammalian cell typically activates the Non-Homologous End Joining (NHEJ) pathway to repair the damage and signal to downstream systems that govern cellular decisions such as apoptosis or senescence. The signalling system also stimulates effects such as...

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Bibliographic Details
Main Authors: Dolan, David, Nelson, Glyn, Zupanic, Anze, Smith, Graham, Shanley, Daryl
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566652/
https://ncbi.nlm.nih.gov/pubmed/23457464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055190
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