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Transition of a microRNA from Repressing to Activating Translation Depending on the Extent of Base Pairing with the Target
MicroRNAs are major post-transcriptional regulators of gene expression. Here we show in the ancient protozoan Giardia lamblia a snoRNA-derived 26-nucleotide microRNA, miR3, which represses the translation of histone H2A mRNA containing an imperfect target but enhances translation when the target is...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3565978/ https://ncbi.nlm.nih.gov/pubmed/23405193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055672 |
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