Essential Role for Rac1 in Cocaine-Induced Structural Plasticity of Nucleus Accumbens Neurons

Repeated cocaine administration increases the dendritic arborization of nucleus accumbens neurons, but the underlying signaling events remain unknown. Here, we show that repeated cocaine negatively regulates the active form of Rac1, a small GTPase that controls actin remodeling in other systems. We...

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Detalhes bibliográficos
Main Authors: Dietz, David M., Sun, Haosheng, Lobo, Mary Kay, Cahill, Michael E., Chadwick, Benjamin, Gao, Virginia, Koo, Ja Wook, Mazei-Robison, Michelle S., Dias, Caroline, Maze, Ian, Damez-Werno, Diane, Dietz, Karen C., Scobie, Kimberly N., Ferguson, Deveroux, Christoffel, Daniel, Ohnishi, Yoko, Hodes, Georgia E., Zheng, Yi, Neve, Rachael L., Hahn, Klaus M., Russo, Scott J., Nestler, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565539/
https://ncbi.nlm.nih.gov/pubmed/22522400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3094
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