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Mutation accumulation and fitness in mutator subpopulations of Escherichia coli

Bacterial populations in clinical and laboratory settings contain a significant proportion of mutants with elevated mutation rates (mutators). Mutators have a particular advantage when multiple beneficial mutations are needed for fitness, as in antibiotic resistance. Nevertheless, high mutation rate...

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Detalhes bibliográficos
Main Authors: Maharjan, Ram P., Liu, Bin, Li, Yang, Reeves, Peter R., Wang, Lei, Ferenci, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565518/
https://ncbi.nlm.nih.gov/pubmed/23221876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsbl.2012.0961
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