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Unphosphorylated STAT1 promotes sarcoma development through repressing expression of Fas and Bad and conferring apoptotic resistance

STAT1 exists in phosphorylated (pSTAT1) and unphosphorylated (uSTAT1) forms each regulated by IFN-γ. Although STAT1 is a key mediator of the IFN-γ signaling pathway, an essential component of the host cancer immunosurveillance system, STAT1 is also overexpressed in certain human cancers where the fu...

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Bibliografske podrobnosti
Main Authors: Zimmerman, Mary A., Rahman, Nur-Taz, Yang, Dafeng, Lahat, Guy, Lazar, Alexander J., Pollock, Raphael, Lev, Dina, Liu, Kebin
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564959/
https://ncbi.nlm.nih.gov/pubmed/22805310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1347
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