Long-Term Inhibition of Xanthine Oxidase by Febuxostat Does Not Decrease Blood Pressure in Deoxycorticosterone Acetate (DOCA)-Salt Hypertensive Rats

Xanthine oxidase and its products, uric acid and ROS, have been implicated in the pathogenesis of cardiovascular disease, such as hypertension. We have previously reported that allopurinol inhibition of XO does not alter the progression of deoxycorticosterone acetate (DOCA)-salt hypertension in rats...

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Autores principales: Szasz, Theodora, Davis, Robert Patrick, Garver, Hannah S., Burnett, Robert J., Fink, Gregory D., Watts, Stephanie W.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564945/
https://ncbi.nlm.nih.gov/pubmed/23393607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056046
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