Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts

BACKGROUND: Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin D [25(OH)D] using genetic markers as instrumental variables (IVs) in bi-dir...

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Main Authors: Vimaleswaran, Karani S., Berry, Diane J., Lu, Chen, Tikkanen, Emmi, Pilz, Stefan, Hiraki, Linda T., Cooper, Jason D., Dastani, Zari, Li, Rui, Houston, Denise K., Wood, Andrew R., Michaëlsson, Karl, Vandenput, Liesbeth, Zgaga, Lina, Yerges-Armstrong, Laura M., McCarthy, Mark I., Dupuis, Josée, Kaakinen, Marika, Kleber, Marcus E., Jameson, Karen, Arden, Nigel, Raitakari, Olli, Viikari, Jorma, Lohman, Kurt K., Ferrucci, Luigi, Melhus, Håkan, Ingelsson, Erik, Byberg, Liisa, Lind, Lars, Lorentzon, Mattias, Salomaa, Veikko, Campbell, Harry, Dunlop, Malcolm, Mitchell, Braxton D., Herzig, Karl-Heinz, Pouta, Anneli, Hartikainen, Anna-Liisa, Streeten, Elizabeth A., Theodoratou, Evropi, Jula, Antti, Wareham, Nicholas J., Ohlsson, Claes, Frayling, Timothy M., Kritchevsky, Stephen B., Spector, Timothy D., Richards, J. Brent, Lehtimäki, Terho, Ouwehand, Willem H., Kraft, Peter, Cooper, Cyrus, März, Winfried, Power, Chris, Loos, Ruth J. F., Wang, Thomas J., Järvelin, Marjo-Riitta, Whittaker, John C., Hingorani, Aroon D., Hyppönen, Elina
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564800/
https://ncbi.nlm.nih.gov/pubmed/23393431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1001383
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