Cholesterol Dependence of Collagen and Echovirus 1 Trafficking along the Novel α2β1 Integrin Internalization Pathway

We have previously shown that soluble collagen and a human pathogen, echovirus 1 (EV1) cluster α2β1 integrin on the plasma membrane and cause their internalization into cytoplasmic endosomes. Here we show that cholesterol plays a major role not only in the uptake of α2β1 integrin and its ligands but...

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Bibliographic Details
Main Authors: Siljamäki, Elina, Rintanen, Nina, Kirsi, Maija, Upla, Paula, Wang, Wei, Karjalainen, Mikko, Ikonen, Elina, Marjomäki, Varpu
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564754/
https://ncbi.nlm.nih.gov/pubmed/23393580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055465
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