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Preferential cellular uptake of amphiphilic macromolecule–lipid complexes with enhanced stability and biocompatibility

Amphiphilic macromolecules (AM) were electrostatically complexed with a 1:1 ratio of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) to form AM–lipid complexes with drug delivery applications. The complexes exist as AM-coated liposomes and th...

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Autors principals: Harmon, Alexander M., Lash, Melissa H., Sparks, Sarah M., Uhrich, Kathryn E.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564574/
https://ncbi.nlm.nih.gov/pubmed/21510986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2011.04.004
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