Mexiletine for Symptoms and Signs of Myotonia in Non-Dystrophic Myotonia: A Randomized Controlled Trial

CONTEXT: Non-dystrophic myotonias (NDM) are rare diseases caused by mutations in skeletal muscle ion channels. Patients experience delayed muscle relaxation causing functionally-limiting stiffness and pain. Mexiletine-induced sodium channel blockade reduced myotonia in case studies and one single bl...

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Autori principali: Statland, Jeffrey M, Bundy, Brian N, Wang, Yunxia, Rayan, Dipa Raja, Trivedi, Jaya R, Sansone, Valeria A, Salajegheh, Mohammad K, Venance, Shannon L., Ciafaloni, Emma, Matthews, Emma, Meola, Giovanni, Herbelin, Laura, Griggs, Robert C, Barohn, Richard J, Hanna, Michael G
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564227/
https://ncbi.nlm.nih.gov/pubmed/23032552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2012.12607
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