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Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells

The cell surface glycoprotein Trask/CDCP1 is phosphorylated during anchorage loss in epithelial cells where it inhibits integrin clustering, outside-in signaling and cell adhesion. Its role in cancer has been difficult to understand, because of the lack of a discernible pattern in its various altera...

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Bibliografiske detaljer
Main Authors: Spassov, Danislav S., Wong, Ching Hang, Wong, Sunny Y., Reiter, Jeremy F., Moasser, Mark M.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563920/
https://ncbi.nlm.nih.gov/pubmed/23243018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2496
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