Myosin VI small insert isoform maintains exocytosis by tethering secretory granules to the cortical actin

Before undergoing neuroexocytosis, secretory granules (SGs) are mobilized and tethered to the cortical actin network by an unknown mechanism. Using an SG pull-down assay and mass spectrometry, we found that myosin VI was recruited to SGs in a Ca(2+)-dependent manner. Interfering with myosin VI funct...

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Main Authors: Tomatis, Vanesa M., Papadopulos, Andreas, Malintan, Nancy T., Martin, Sally, Wallis, Tristan, Gormal, Rachel S., Kendrick-Jones, John, Buss, Folma, Meunier, Frédéric A.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2013
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563687/
https://ncbi.nlm.nih.gov/pubmed/23382463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201204092
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