Pax4 is not essential for beta-cell differentiation in zebrafish embryos but modulates alpha-cell generation by repressing arx gene expression

BACKGROUND: Genetic studies in mouse have demonstrated the crucial function of PAX4 in pancreatic cell differentiation. This transcription factor specifies β- and δ-cell fate at the expense of α-cell identity by repressing Arx gene expression and ectopic expression of PAX4 in α-cells is sufficient t...

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Autori principali: Djiotsa, Joachim, Verbruggen, Vincianne, Giacomotto, Jean, Ishibashi, Minaka, Manning, Elisabeth, Rinkwitz, Silke, Manfroid, Isabelle, L Voz, Marianne, Peers, Bernard
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563606/
https://ncbi.nlm.nih.gov/pubmed/23244389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-12-37
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