Exploiting MEK Inhibitor-Mediated Activation of ERα for Therapeutic Intervention in ER-Positive Ovarian Carcinoma

While the clinical benefit of MEK inhibitor (MEKi)-based therapy is well established in Raf mutant malignancies, its utility as a suppressor of hyperactive MAPK signaling in the absence of mutated Raf or Ras, is an area of ongoing research. MAPK activation is associated with loss of ERα expression a...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Hou, June Y., Rodriguez-Gabin, Alicia, Samaweera, Leleesha, Hazan, Rachel, Goldberg, Gary L., Horwitz, Susan Band, McDaid, Hayley M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563537/
https://ncbi.nlm.nih.gov/pubmed/23390495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054103
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker