Intravenous Delivery of HIV-Based Lentiviral Vectors Preferentially Transduces F4/80+ and Ly-6C+ Cells in Spleen, Important Target Cells in Autoimmune Arthritis

Antigen presenting cells (APCs) play an important role in arthritis and APC specific gene therapeutic targeting will enable intracellular modulation of cell activity. Viral mediated overexpression is a potent approach to achieve adequate transgene expression levels and lentivirus (LV) is useful for...

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Main Authors: van den Brand, Ben T., Vermeij, Eline A., Waterborg, Claire E. J., Arntz, Onno J., Kracht, Michael, Bennink, Miranda B., van den Berg, Wim B., van de Loo, Fons A. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563527/
https://ncbi.nlm.nih.gov/pubmed/23390530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055356
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