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Denoising PCR-amplified metagenome data

BACKGROUND: PCR amplification and high-throughput sequencing theoretically enable the characterization of the finest-scale diversity in natural microbial and viral populations, but each of these methods introduces random errors that are difficult to distinguish from genuine biological diversity. Sev...

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Detalhes bibliográficos
Main Authors: Rosen, Michael J, Callahan, Benjamin J, Fisher, Daniel S, Holmes, Susan P
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563472/
https://ncbi.nlm.nih.gov/pubmed/23113967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-13-283
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