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Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1
The human sensor of double-stranded RNA (dsRNA) oligoadenylate synthetase 1 (hOAS1) polymerizes ATP into 2′,5′-linked iso-RNA (2-5A) involved in innate immunity, cell cycle, and differentiation. We report the crystal structure of hOAS1 in complex with dsRNA and 2′-deoxy ATP at 2.7 Å resolution, whic...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3562804/ https://ncbi.nlm.nih.gov/pubmed/23319625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218528110 |
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