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Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila

A flagellin-independent caspase-1 activation pathway that does not require NAIP5 or NRLC4 is induced by the intracellular pathogen Legionella pneumophila. Here we demonstrate that this pathway requires caspase-11. Treatment of macrophages with LPS up-regulated the host components required for this c...

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Detalhes bibliográficos
Main Authors: Case, Christopher L., Kohler, Lara J., Lima, Jonilson B., Strowig, Till, de Zoete, Marcel R., Flavell, Richard A., Zamboni, Dario S., Roy, Craig R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562791/
https://ncbi.nlm.nih.gov/pubmed/23307811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211521110
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