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Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila
A flagellin-independent caspase-1 activation pathway that does not require NAIP5 or NRLC4 is induced by the intracellular pathogen Legionella pneumophila. Here we demonstrate that this pathway requires caspase-11. Treatment of macrophages with LPS up-regulated the host components required for this c...
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3562791/ https://ncbi.nlm.nih.gov/pubmed/23307811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211521110 |
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