Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53

The tumour suppressor p53 is the most frequently mutated gene in human cancer. Reactivation of mutant p53 by small molecules is an exciting potential cancer therapy. Although several compounds restore wild-type function to mutant p53, their binding sites and mechanisms of action are elusive. Here co...

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Bibliografiske detaljer
Main Authors: Wassman, Christopher D., Baronio, Roberta, Demir, Özlem, Wallentine, Brad D., Chen, Chiung-Kuang, Hall, Linda V., Salehi, Faezeh, Lin, Da-Wei, Chung, Benjamin P., Wesley Hatfield, G., Richard Chamberlin, A., Luecke, Hartmut, Lathrop, Richard H., Kaiser, Peter, Amaro, Rommie E.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562459/
https://ncbi.nlm.nih.gov/pubmed/23360998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2361
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