Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans

Caffeine induces locomotor activation by its ability to block adenosine receptors. Caffeine is metabolized to several methylxanthines, with paraxanthine being the main metabolite in humans. In this study we show that in rats paraxanthine has a stronger locomotor activating effect than caffeine or th...

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Detalhes bibliográficos
Main Authors: Orrú, Marco, Guitart, Xavier, Karcz-Kubicha, Marzena, Solinas, Marcello, Justinova, Zuzana, Barodia, Sandeep Kumar, Zanoveli, Janaina, Cortes, Antoni, Lluis, Carme, Casado, Vicent, Moeller, F. Gerard, Ferré, Sergi
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562388/
https://ncbi.nlm.nih.gov/pubmed/23261866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2012.11.029
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