Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans

Caffeine induces locomotor activation by its ability to block adenosine receptors. Caffeine is metabolized to several methylxanthines, with paraxanthine being the main metabolite in humans. In this study we show that in rats paraxanthine has a stronger locomotor activating effect than caffeine or th...

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Autori principali: Orrú, Marco, Guitart, Xavier, Karcz-Kubicha, Marzena, Solinas, Marcello, Justinova, Zuzana, Barodia, Sandeep Kumar, Zanoveli, Janaina, Cortes, Antoni, Lluis, Carme, Casado, Vicent, Moeller, F. Gerard, Ferré, Sergi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562388/
https://ncbi.nlm.nih.gov/pubmed/23261866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2012.11.029
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