Pro- and anti-apoptotic effects of p53 in cisplatin-treated human testicular cancer are cell context-dependent

In murine testicular cancer (TC) cells wild-type p53 contributes to sensitivity to DNA-damaging drugs in a dose-dependent way. In human TC, however, the role of wild-type p53 functionality in chemotherapeutic response remains elusive. We analyzed functionality of wild-type p53 in cisplatin sensitivi...

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Detalhes bibliográficos
Main Authors: di Pietro, Alessandra, Koster, Roelof, Boersma-van Eck, Wytske, Dam, Wendy A., Mulder, Nanno H., Gietema, Jourik A., de Vries, Elisabeth G.E., de Jong, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562300/
https://ncbi.nlm.nih.gov/pubmed/23165211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22803
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