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Frequency and Prognostic Impact of CEBPA Proximal, Distal and Core Promoter Methylation in Normal Karyotype AML: A Study on 623 Cases

The clinical impact of aberrant CEBPA promoter methylation (PM) in AML is controversially discussed. The aim of this study was to clarify the significance of aberrant CEBPA PM with regard to clinical features in a cohort of 623 cytogenetically normal (CN) de novo AML. 555 cases had wild-type CEBPA,...

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Autori principali: Fasan, Annette, Alpermann, Tamara, Haferlach, Claudia, Grossmann, Vera, Roller, Andreas, Kohlmann, Alexander, Eder, Christiane, Kern, Wolfgang, Haferlach, Torsten, Schnittger, Susanne
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562230/
https://ncbi.nlm.nih.gov/pubmed/23383300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054365
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