High-throughput sequence analysis reveals structural diversity and improved potency among RNA inhibitors of HIV reverse transcriptase

Systematic evolution of ligands through exponential enrichment (SELEX) is a well-established method for generating nucleic acid populations that are enriched for specified functions. High-throughput sequencing (HTS) enhances the power of comparative sequence analysis to reveal details of how RNAs wi...

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Main Authors: Ditzler, Mark A., Lange, Margaret J., Bose, Debojit, Bottoms, Christopher A., Virkler, Katherine F., Sawyer, Andrew W., Whatley, Angela S., Spollen, William, Givan, Scott A., Burke, Donald H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561961/
https://ncbi.nlm.nih.gov/pubmed/23241386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1190
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