Targeted gene silencing in mouse germ cells by insertion of a homologous DNA into a piRNA generating locus

In germ cells, early embryos, and stem cells of animals, PIWI-interacting RNAs (piRNAs) have an important role in silencing retrotransposons, which are vicious genomic parasites, through transcriptional and post-transcriptional mechanisms. To examine whether the piRNA pathway can be used to silence...

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Autori principali: Yamamoto, Yasuhiro, Watanabe, Toshiaki, Hoki, Yuko, Shirane, Kenjiro, Li, Yufeng, Ichiiyanagi, Kenji, Kuramochi-Miyagawa, Satomi, Toyoda, Atsushi, Fujiyama, Asao, Oginuma, Masayuki, Suzuki, Hitomi, Sado, Takashi, Nakano, Toru, Sasaki, Hiroyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561870/
https://ncbi.nlm.nih.gov/pubmed/23132912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.137224.112
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