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Ubiquitylation and the pathogenesis of hypertension

Liddle syndrome is monogenic hypertension caused by mutations in the epithelial Na(+) channel (ENaC) that interfere with its ubiquitylation by Nedd4-2. In this issue, Ronzaud and colleagues found that deleting Nedd4-2 from kidney tubules in adult mice led to ENaC accumulation, but not at the plasma...

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Detalles Bibliográficos
Autor Principal: Ellison, David H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561829/
https://ncbi.nlm.nih.gov/pubmed/23348731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66882
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