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Ubiquitylation and the pathogenesis of hypertension
Liddle syndrome is monogenic hypertension caused by mutations in the epithelial Na(+) channel (ENaC) that interfere with its ubiquitylation by Nedd4-2. In this issue, Ronzaud and colleagues found that deleting Nedd4-2 from kidney tubules in adult mice led to ENaC accumulation, but not at the plasma...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3561829/ https://ncbi.nlm.nih.gov/pubmed/23348731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66882 |
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