Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

Alzheimer's disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ) in the brain because of an imbalance between Aβ production and clearance. Neprilysin (NEP) is the most important Aβ-degrading enzyme in the brain. Thus, researchers have explored virus-mediated NEP gene deli...

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Autores principales: Katsuda, Takeshi, Tsuchiya, Reiko, Kosaka, Nobuyoshi, Yoshioka, Yusuke, Takagaki, Kentaro, Oki, Katsuyuki, Takeshita, Fumitaka, Sakai, Yasuyuki, Kuroda, Masahiko, Ochiya, Takahiro
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561625/
https://ncbi.nlm.nih.gov/pubmed/23378928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01197
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