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Distinct Roles in Autophagy and Importance in Infectivity of the Two ATG4 Cysteine Peptidases of Leishmania major

Macroautophagy in Leishmania, which is important for the cellular remodeling required during differentiation, relies upon the hydrolytic activity of two ATG4 cysteine peptidases (ATG4.1 and ATG4.2). We have investigated the individual contributions of each ATG4 to Leishmania major by generating indi...

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Detalhes bibliográficos
Main Authors: Williams, Roderick A. M., Mottram, Jeremy C., Coombs, Graham H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561585/
https://ncbi.nlm.nih.gov/pubmed/23166325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415372
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