Matrix Metalloproteinase-9 Reduces Islet Amyloid Formation by Degrading Islet Amyloid Polypeptide

Deposition of islet amyloid polypeptide (IAPP) as amyloid is a pathological hallmark of the islet in type 2 diabetes, which is toxic to β-cells. We previously showed that the enzyme neprilysin reduces islet amyloid deposition and thereby reduces β-cell apoptosis, by inhibiting fibril formation. Two...

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Main Authors: Aston-Mourney, Kathryn, Zraika, Sakeneh, Udayasankar, Jayalakshmi, Subramanian, Shoba L., Green, Pattie S., Kahn, Steven E., Hull, Rebecca L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561574/
https://ncbi.nlm.nih.gov/pubmed/23229548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.438457
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