Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD(+) Biosynthesis, in Human Cancer Cells: METABOLIC BASIS AND POTENTIAL CLINICAL IMPLICATIONS

Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the first rate-limiting step in converting nicotinamide to NAD(+), essential for cellular metabolism, energy production, and DNA repair. NAMPT has been extensively studied because of its critical role in these cellular processes and the prospe...

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Détails bibliographiques
Auteurs principaux: Tan, Bo, Young, Debra A., Lu, Zhao-Hai, Wang, Tao, Meier, Timothy I., Shepard, Robert L., Roth, Kenneth, Zhai, Yan, Huss, Karen, Kuo, Ming-Shang, Gillig, James, Parthasarathy, Saravanan, Burkholder, Timothy P., Smith, Michele C., Geeganage, Sandaruwan, Zhao, Genshi
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2013
Sujets:
Metabolism
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561569/
https://ncbi.nlm.nih.gov/pubmed/23239881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.394510
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