NEU3 Sialidase Is Activated under Hypoxia and Protects Skeletal Muscle Cells from Apoptosis through the Activation of the Epidermal Growth Factor Receptor Signaling Pathway and the Hypoxia-inducible Factor (HIF)-1α

NEU3 sialidase, a key enzyme in ganglioside metabolism, is activated under hypoxic conditions in cultured skeletal muscle cells (C2C12). NEU3 up-regulation stimulates the EGF receptor signaling pathway, which in turn activates the hypoxia-inducible factor (HIF-1α), resulting in a final increase of c...

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Hlavní autoři: Scaringi, Raffaella, Piccoli, Marco, Papini, Nadia, Cirillo, Federica, Conforti, Erika, Bergante, Sonia, Tringali, Cristina, Garatti, Andrea, Gelfi, Cecilia, Venerando, Bruno, Menicanti, Lorenzo, Tettamanti, Guido, Anastasia, Luigi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Glycobiology and Extracellular Matrices
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561537/
https://ncbi.nlm.nih.gov/pubmed/23209287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404327
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