Identification of RNF8 as a Ubiquitin Ligase Involved in Targeting the p12 Subunit of DNA Polymerase δ for Degradation in Response to DNA Damage

DNA polymerase δ consists of four subunits, one of which, p12, is degraded in response to DNA damage through the ubiquitin-proteasome pathway. However, the identities of the ubiquitin ligase(s) that are responsible for the proximal biochemical events in triggering proteasomal degradation of p12 are...

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Detalhes bibliográficos
Main Authors: Zhang, Sufang, Zhou, Yajing, Sarkeshik, Ali, Yates, John R., Thomson, Timothy M., Zhang, Zhongtao, Lee, Ernest Y. C., Lee, Marietta Y. W. T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561517/
https://ncbi.nlm.nih.gov/pubmed/23233665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.423392
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