Arsenic Suppresses Cell Survival via Pirh2-mediated Proteasomal Degradation of ΔNp63 Protein

Transcription factor p63, a member of the p53 family, shares a high degree of sequence similarity with p53. Because of transcription from two distinct promoters, the p63 gene encodes two isoforms, TAp63 and ΔNp63. Although TAp63 acts as a tumor suppressor, ΔNp63 functions as an oncogene and is often...

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Bibliographic Details
Main Authors: Yan, Wensheng, Chen, Xiufang, Zhang, Yanhong, Zhang, Jin, Jung, Yong-Sam, Chen, Xinbin
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561513/
https://ncbi.nlm.nih.gov/pubmed/23271742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.428607
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