Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma

Platelet factor 4 (PF4) is an angiostatic chemokine that suppresses tumor growth and metastasis. We previously revealed frequent transcriptional silencing of PF4 in multiple myeloma, but the functional roles of this chemokine are still unknown. We studied the apoptotic effects of PF4 on myeloma cell...

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Bibliografiske detaljer
Main Authors: Liang, Pei, Cheng, Suk Hang, Cheng, Chi Keung, Lau, Kin Mang, Lin, Shek Ying, Chow, Eudora Y.D., Chan, Natalie P.H., Ip, Rosalina K.L., Wong, Raymond S.M., Ng, Margaret H. L.
Format: Artigo
Sprog:Inglês
Udgivet: Ferrata Storti Foundation 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561438/
https://ncbi.nlm.nih.gov/pubmed/22929979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.065607
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