mTOR Inhibitors Alone and in Combination with JAK2 Inhibitors Effectively Inhibit Cells of Myeloproliferative Neoplasms

BACKGROUND: Dysregulated signaling of the JAK/STAT pathway is a common feature of chronic myeloproliferative neoplasms (MPN), usually associated with JAK2V617F mutation. Recent clinical trials with JAK2 inhibitors showed significant improvements in splenomegaly and constitutional symptoms in patient...

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Main Authors: Bogani, Costanza, Bartalucci, Niccolò, Martinelli, Serena, Tozzi, Lorenzo, Guglielmelli, Paola, Bosi, Alberto, Vannucchi, Alessandro M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2013
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561413/
https://ncbi.nlm.nih.gov/pubmed/23382981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054826
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