Relevance of TNBS-Colitis in Rats: A Methodological Study with Endoscopic, Histologic and Transcriptomic Characterization and Correlation to IBD

BACKGROUND: Rectal instillation of trinitrobenzene sulphonic acid (TNBS) in ethanol is an established model for inflammatory bowel disease (IBD). We aimed to 1) set up a TNBS-colitis protocol resulting in an endoscopic and histologic picture resembling IBD, 2) study the correlation between endoscopi...

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Detalhes bibliográficos
Main Authors: Brenna, Øystein, Furnes, Marianne W., Drozdov, Ignat, van Beelen Granlund, Atle, Flatberg, Arnar, Sandvik, Arne K., Zwiggelaar, Rosalie T. M., Mårvik, Ronald, Nordrum, Ivar S., Kidd, Mark, Gustafsson, Björn I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561356/
https://ncbi.nlm.nih.gov/pubmed/23382912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054543
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