Dissection of Ire1 Functions Reveals Stress Response Mechanisms Uniquely Evolved in Candida glabrata

Proper protein folding in the endoplasmic reticulum (ER) is vital in all eukaryotes. When misfolded proteins accumulate in the ER lumen, the transmembrane kinase/endoribonuclease Ire1 initiates splicing of HAC1 mRNA to generate the bZIP transcription factor Hac1, which subsequently activates its tar...

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Hlavní autoři: Miyazaki, Taiga, Nakayama, Hironobu, Nagayoshi, Yohsuke, Kakeya, Hiroshi, Kohno, Shigeru
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561209/
https://ncbi.nlm.nih.gov/pubmed/23382685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003160
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