Inhibition of COX-2 expression by topical diclofenac enhanced radiation sensitivity via enhancement of TRAIL in human prostate adenocarcinoma xenograft model

BACKGROUND: COX-2 inhibitors have an antitumor potential and have been verified by many researchers. Treatment of cancer cells with external stressors such as irradiation can stimulate the over-expression of COX-2 and possibly confer radiation resistance. In this study, we tested if topical diclofen...

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Hauptverfasser: Inoue, Takeshi, Anai, Satoshi, Onishi, Sayuri, Miyake, Makito, Tanaka, Nobumichi, Hirayama, Akihide, Fujimoto, Kiyohide, Hirao, Yoshihiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561196/
https://ncbi.nlm.nih.gov/pubmed/23289871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2490-13-1
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