Inhibition of COX-2 expression by topical diclofenac enhanced radiation sensitivity via enhancement of TRAIL in human prostate adenocarcinoma xenograft model

<p>Abstract</p> <p>Background</p> <p>COX-2 inhibitors have an antitumor potential and have been verified by many researchers. Treatment of cancer cells with external stressors such as irradiation can stimulate the over-expression of COX-2 and possibly confer radiation r...

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Detalhes bibliográficos
Main Authors: Inoue Takeshi, Anai Satoshi, Onishi Sayuri, Miyake Makito, Tanaka Nobumichi, Hirayama Akihide, Fujimoto Kiyohide, Hirao Yoshihiko
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2013-01-01
Colecção:BMC Urology
Assuntos:
Prostate cancer
Radiation therapy
COX-2
TRAIL
Apoptosis
Topical therapy
Radiosensitizer
Diclofenac
Radioresistance
Acesso em linha:http://www.biomedcentral.com/1471-2490/13/1
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