Discovery of a Siderophore Export System Essential for Virulence of Mycobacterium tuberculosis

Iron is an essential nutrient for most bacterial pathogens, but is restricted by the host immune system. Mycobacterium tuberculosis (Mtb) utilizes two classes of small molecules, mycobactins and carboxymycobactins, to capture iron from the human host. Here, we show that an Mtb mutant lacking the mmp...

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Main Authors: Wells, Ryan M., Jones, Christopher M., Xi, Zhaoyong, Speer, Alexander, Danilchanka, Olga, Doornbos, Kathryn S., Sun, Peibei, Wu, Fangming, Tian, Changlin, Niederweis, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561183/
https://ncbi.nlm.nih.gov/pubmed/23431276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003120
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