Preclinical evaluation of carbon-11 and fluorine-18 sulfonamide derivatives for in vivo radiolabeling of erythrocytes

BACKGROUND: To date, few PET tracers for in vivo labeling of red blood cells (RBCs) are available. In this study, we report the radiosynthesis and in vitro and in vivo evaluation of (11)C and (18)F sulfonamide derivatives targeting carbonic anhydrase II (CA II), a metallo-enzyme expressed in RBCs, a...

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Autori principali: Gheysens, Olivier, Akurathi, Vamsidhar, Chekol, Rufael, Dresselaers, Tom, Celen, Sofie, Koole, Michel, Dauwe, Dieter, Cleynhens, Bernard J, Claus, Piet, Janssens, Stefan, Verbruggen, Alfons M, Nuyts, Johan, Himmelreich, Uwe, Bormans, Guy M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer 2013
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561128/
https://ncbi.nlm.nih.gov/pubmed/23316861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2191-219X-3-4
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