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Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction

Systemic and oral clearances of alfentanil are in vivo probes for hepatic and first-pass CYP3A. Both alfentanil single point plasma concentrations and miosis are surrogates for area under the concentration-time curve (AUC), clearance, and are minimal and non-invasive CYP3A probes. This investigation...

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Bibliografski detalji
Glavni autori: Kharasch, Evan D., Francis, Amber, London, Amy, Frey, Karen, Kim, Thomas, Blood, Jane
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3560934/
https://ncbi.nlm.nih.gov/pubmed/21562488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2011.59
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