Indoleamine-2,3-dioxygenase activity in experimental human endotoxemia

BACKGROUND: Excessive tryptophan metabolism to kynurenine by the rate-limiting enzyme endothelial indoleamine 2,3-dioxygenase 1 (IDO) controls arterial vessel relaxation and causes hypotension in murine endotoxemia. However, its relevance in human endotoxemia has not been investigated so far. We thu...

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Detalhes bibliográficos
Main Authors: Padberg, Jan-Sören, Van Meurs, Matijs, Kielstein, Jan T, Martens-Lobenhoffer, Jens, Bode-Böger, Stefanie M, Zijlstra, Jan G, Kovesdy, Csaba P, Kümpers, Philipp
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3560239/
https://ncbi.nlm.nih.gov/pubmed/23216784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2040-7378-4-24
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