Aerosolized Gamma Interferon (IFN-γ) Induces Expression of the Genes Encoding the IFN-γ-Inducible 10-Kilodalton Protein but Not Inducible Nitric Oxide Synthase in the Lung during Tuberculosis

Gamma interferon (IFN-γ) is critical in the immune response against Mycobacterium tuberculosis. In an ongoing trial of aerosol IFN-γ in conjunction with standard drug therapy, we have observed activation of IFN signaling in bronchoalveolar lavage (BAL) cells from tuberculosis (TB) patients. We hypot...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Raju, Bindu, Hoshino, Yoshihiko, Kuwabara, Kenichi, Belitskaya, Ilana, Prabhakar, Savita, Canova, Antony, Gold, Jeffrey A., Condos, Rany, Pine, Richard I., Brown, Stuart, Rom, William N., Weiden, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2004
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC356013/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14977928/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.72.3.1275-1283.2004
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