Copy Number Variations in Alternative Splicing Gene Networks Impact Lifespan

Longevity has a strong genetic component evidenced by family-based studies. Lipoprotein metabolism, FOXO proteins, and insulin/IGF-1 signaling pathways in model systems have shown polygenic variations predisposing to shorter lifespan. To test the hypothesis that rare variants could influence lifespa...

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Bibliografiset tiedot
Päätekijät: Glessner, Joseph T., Smith, Albert Vernon, Panossian, Saarene, Kim, Cecilia E., Takahashi, Nagahide, Thomas, Kelly A., Wang, Fengxiang, Seidler, Kallyn, Harris, Tamara B., Launer, Lenore J., Keating, Brendan, Connolly, John, Sleiman, Patrick M. A., Buxbaum, Joseph D., Grant, Struan F. A., Gudnason, Vilmundur, Hakonarson, Hakon
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2013
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3559729/
https://ncbi.nlm.nih.gov/pubmed/23382853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053846
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