Copy Number Variations in Alternative Splicing Gene Networks Impact Lifespan

Longevity has a strong genetic component evidenced by family-based studies. Lipoprotein metabolism, FOXO proteins, and insulin/IGF-1 signaling pathways in model systems have shown polygenic variations predisposing to shorter lifespan. To test the hypothesis that rare variants could influence lifespa...

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Detalhes bibliográficos
Main Authors: Glessner, Joseph T., Smith, Albert Vernon, Panossian, Saarene, Kim, Cecilia E., Takahashi, Nagahide, Thomas, Kelly A., Wang, Fengxiang, Seidler, Kallyn, Harris, Tamara B., Launer, Lenore J., Keating, Brendan, Connolly, John, Sleiman, Patrick M. A., Buxbaum, Joseph D., Grant, Struan F. A., Gudnason, Vilmundur, Hakonarson, Hakon
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3559729/
https://ncbi.nlm.nih.gov/pubmed/23382853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053846
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