MTN-001: Randomized Pharmacokinetic Cross-Over Study Comparing Tenofovir Vaginal Gel and Oral Tablets in Vaginal Tissue and Other Compartments

BACKGROUND: Oral and vaginal preparations of tenofovir as pre-exposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) infection have demonstrated variable efficacy in men and women prompting assessment of variation in drug concentration as an explanation. Knowledge of tenofovir concentrat...

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Autors principals: Hendrix, Craig W., Chen, Beatrice A., Guddera, Vijayanand, Hoesley, Craig, Justman, Jessica, Nakabiito, Clemensia, Salata, Robert, Soto-Torres, Lydia, Patterson, Karen, Minnis, Alexandra M., Gandham, Sharavi, Gomez, Kailazarid, Richardson, Barbra A., Bumpus, Namandje N.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3559346/
https://ncbi.nlm.nih.gov/pubmed/23383037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055013
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