Integrating High-Content Imaging and Chemical Genetics to Probe Host Cellular Pathways Critical for Yersinia Pestis Infection

The molecular machinery that regulates the entry and survival of Yersinia pestis in host macrophages is poorly understood. Here, we report the development of automated high-content imaging assays to quantitate the internalization of virulent Y. pestis CO92 by macrophages and the subsequent activatio...

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Hauptverfasser: Kota, Krishna P., Eaton, Brett, Lane, Douglas, Ulrich, Melanie, Ulrich, Ricky, Peyser, Brian D., Robinson, Camenzind G., Jaissle, James G., Pegoraro, Gianluca, Bavari, Sina, Panchal, Rekha G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3559335/
https://ncbi.nlm.nih.gov/pubmed/23383093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055167
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